What Are Antibody Drug Conjugates?
Antibody-drug conjugates (ADCs) combine the high specificity of monoclonal antibody drugs with the high activity of small-molecule cytotoxic drugs to improve the targeting of tumor drugs and reduce toxic and side effects. The antibody portion of the ADC binds to proteins on the surface of cancer cells, and the entire complex is then internalized into the cell. Once inside, the drug portion of the ADC is released and kills the cancer cell by disrupting vital cellular processes.
ADCs have several advantages over traditional chemotherapy, including higher specificity and lower toxicity. They are also highly effective at killing cancer cells, making them promising new treatments for many types of cancer.
Mechanism of antibody-drug conjugate (ADC) action. 
What We Do for Antibody Drug Conjugates
Due to the complex structure of ADC drugs and large differences among different ADC drug designs, the process of ADC design and synthesis can be a time-consuming and challenging task. At Alfa Chemistry, we offer a comprehensive range of design and synthesis services for ADCs, which include antibody selection, linker design, and the conjugation of small molecule drugs. Our team of experienced chemists has extensive expertise in the development of ADCs, and we are committed to providing our clients with customized solutions that meet their specific needs and requirements.
- Computer Aided Design and Optimization of ADCs
At Alfa Chemistry, we leverage the power of computational chemistry to develop ADCs with higher potency and minimize project time and cost. Our design and optimization computational methods for ADCs include:
Molecular docking and molecular dynamics simulations for designing ADCs 
- Automated Synthesis of ADCs
Relying on the advanced automated synthesis platform and experienced synthetic chemists, Alfa Chemistry is ready to provide customers with efficient and high-quality ADCs synthesis solutions. We can design and synthesize antibody drug conjugates through a variety of functional groups, just to name a few:
Choose Alfa Chemistry
With our unparalleled expertise and commitment to quality, Alfa Chemistry is poised to help drive the next wave of innovation in drug discovery through our ADC design and synthesis services. To get started with our services, or to discuss our capabilities with a member of our expert team, contact us today.
- Utsab Debnath, et al. Journal of Molecular Structure, 2022, 1256, 132524.
- Nimish Gupta, et al. Nature Biomedical Engineering, 2019, 3, 917-929.
- Rita Melo, et al. Curr Top Med Chem., 2018, 18, 1091-1109.